Ubudlelwano obuncike ekuthembekeni komthamo phakathi kokuvezwa kwe-mercury kusuka kuma-amalgamu wamazinyo kanye nama-biomarker obuqotho bezinso: Ukuhlolwa okuqhubekayo kwesilingo se-amalgam sezingane saseCasa Pia
I-DA Geier, T Carmody, JK Kern, PG King noMnu Geier
I-Toxicology Yomuntu Neyokuhlola 32 (4) 434-440. 2013.
abstract
Ama-amalgamu wamazinyo ayizinto zokubuyiselwa kwamazinyo ezisetshenziswa kakhulu. Ama-Amalgam acishe abe yi-50% ye-mercury (Hg), kanti i-Hg yaziwa ngokuqongelela kakhulu ezinso. Kwakucatshangwa ukuthi ngenxa yokuthi i-Hg iqoqa kuma-tubules (PTs), i-glutathione-S-transferases (GST) -a (ephakamisa ukulimala kwezinso ezingeni le-PT) kulindeleke ukuthi ihlobene kakhulu nokuvezwa kwe-Hg kune-GST-p (okuphakamisa ukulimala kwezinso ezingeni lama-tubules e-distal). Ama-urinary biomarkers wobuqotho bezinso ahlolwe ezinganeni ezineminyaka engu-8-18 ubudala, nokugcwaliswa nangaphandle kwamazinyo kwe-amalgam, kusuka esivivinyweni somtholampilo esiqediwe (isifundo somzali).
Ukutadisha kwethu kunqume ukuthi ngabe kukhona ukuhlobana okukhulu okuncike kumthamo phakathi kokukhuphuka kokuvezwa kwe-Hg kusuka kuma-amalgams wamazinyo kanye ne-GST-a ne-GST-p njengama-biomarkers obuqotho bezinso. Kukonke, isifundo samanje, sisebenzisa imodeli yezibalo ehlukile futhi ebucayi ukwedlula isifundo somzali, iveze ukuhlangana okuphawulekayo ngokwezibalo ezincike kumthamo phakathi kokuchayeka kokuqoqeka ku-Hg kusuka kuma-amalgams wamazinyo namazinga we-urinary we-GST-a, ngemuva kokulungiswa kwe-covariate; lapho njengoba, ubudlelwano obungabalulekile babonwa ngamazinga wokuchama we-GST-p. Ngaphezu kwalokho, kwabonwa ukuthi amazinga e-urinary GST-a enyuke cishe ngo-10% phakathi nenkambo yeminyaka eyisishiyagalombili yocwaningo phakathi kwabantu abanokuvezwa okulingene kwama-amalgamu phakathi kwezifundo zocwaningo ezivela eqenjini le-amalgam, uma kuqhathaniswa nezifundo ezifundwayo ngaphandle kokuvezwa kuma-amalgams wamazinyo.
Imiphumela yocwaningo lwethu iphakamisa ukuthi ama-amalgamu wamazinyo afaka isandla ekulimaleni kwezinso okuqhubekayo ezingeni lama-PT ngendlela encike kumthamo.
Buka yonke i-athikili: Ukulimala Kwezinso zeGeier 2013
