Kunokukhathazeka okukhulu phakathi kososayensi nomphakathi mayelana nezinto ezilingisa ama-hormone zezinto eziningi zamakhemikhali zepulasitiki, kufaka phakathi lezo ezitholakala kokuhlanganiswa kwamazinyo. I-resin ye-Bis-GMA esetshenziswa kakhulu isebenzisa enye yezimpikiswano kakhulu yalezi, iBisphenol-A (BPA). Abakhiqizi abahlangene ababhekele phambili bathi ayikho i-BPA engaphendulwanga ezinhlakeni zamazinyo, nokuthi kuthatha amazinga okushisa aphezulu - ama-degree angamakhulu amaningana - ukukhulula i-BPA yamahhala. Abanye abagxeki bathi, eqinisweni, izibopho ze-ester kuma-resins zingaphansi kwe-hydrolysis, futhi i-BPA ingakhishwa ngobuningi obungalinganiswa. Siyazi ukuthi ama-sealants wamazinyo angahluka enanini le-BPA avuzayo (Inkomba), kepha njengamanje ayikho inhlolovo enhle ye-in vitro yokuthi ingakanani i-BPA ekhululwe yimikhiqizo emikhulu yama-resins ahlanganisiwe. Futhi, siyazi ukuthi umhlaba ugcwele amakhemikhali epulasitiki, futhi yonke into ephilayo emhlabeni inezinga lezicubu elilinganisekayo le-BPA. Asazi ngempela ukuthi inani le-BPA elikhishwe kumhlanganiso wamazinyo lanele yini ukukhulisa ukuvezwa komuntu ngaphezu kwezinga lesizinda semvelo, noma uma lingabalulekile ngempela. Izindatshana ezifakiwe zichaza uhla lwezinkinga eziphenywayo.
Ngo-2008, i-IAOMT yenza ucwaningo lwelabhoratri lokukhishwa kwe-BPA ohlangothini lwezinhlanganisela zamazinyo ezitholakalayo ezentengiselwano ngaphansi kwezimo zomzimba: 37º C, pH 7.0 kanye ne-pH 5.5. Ngeshwa, ngenxa yezinguquko ekuphathweni kwelebhu yasenyuvesi lapho kwenziwa khona lolu cwaningo, kuye kwadingeka ukuthi sisheshe sisheshe siqede ukwedlula obekuhleliwe, futhi nemininingwane esiyitholile ingathathwa njengeyokuqala nje. Inani elilinganisiwe le-BPA litholakale lilinganisa izinhlanganisela. Babesezingeni eliphansi-ngezigidigidi zamabanga ngemuva kwamahora angama-24, ngoku-oda kwenkulungwane eyodwa yokuvezwa kwansuku zonke kwabantu abadala emhlabeni othuthukile. Le miphumela yethulwa engqungqutheleni ye-IAOMT eyayiseSan Antonio ngoMashi 2009, kanti isifundo esiphelele siyatholakala ukuthi sibukwe ngu- ngokuchofoza lapha. Amaslayidi wephoyinti lamandla afakiwe, anesihloko esithi "San Antonio BPA." Imiphumela yamasampula ahlanganisiwe ngakunye ikusilayidi 22 saleso sethulo
Ngo-2011, i-IAOMT yenze iphrojekthi encane ngesikali sePlastipure, Inc. e-Austin, eTexas, ukubona ukuthi ngabe akukho yini okukhombisa umsebenzi we-estrogen kusuka ezingxenyeni zamazinyo ngaphansi kwezimo zomzimba. Sibheke umsebenzi we-estrogen hhayi ngokuqondile ovela ku-BPA, kodwa kunoma yiziphi izinhlobo eziningi zamakhemikhali ezingalingisa ama-estrogens. Futhi, ngenxa yezizathu ezingaphezu kwamandla ethu, leyo lebhu ivaliwe futhi, ngaphambi kokuthi sandise isifundo siye ezingeni lokushicilelwa. Kepha ezingeni lesifundo sokushayela esiliqedile, akukho msebenzi we-estrogenic otholakele, ngaphansi kwezimo zomzimba zokushisa komzimba ne-pH.
I-athikili ethi "Ukubuyekezwa kwe-BPA" imele umbono osuselwe ku-toxicology ejwayelekile, ebesithembele kuyo esikhathini esedlule. Le ndatshana ibukeza imibhalo ngokuvezwa uma kuqhathaniswa nedatha yomkhawulo enobuthi ye-bishpenol-A (BPA) evela ezingxenyeni zamazinyo nezinsimbi, futhi iqinisekisa ukuthi ukuvezwa okwaziwayo kungaphansi kakhulu komthamo onobuthi owaziwayo.
Kodwa-ke, udaba lokungenzeka kokusebenza kwamahomoni ngamanani amancane ngokweqile we-BPA nokunye ukulingiswa kwamahomoni, ezingxenyeni zebanga ngalinye nangaphansi, kuveza izinkinga ezingakhulunywa ngazo kubuthi obujwayelekile. Kumodeli ejwayelekile, imiphumela yedosi ephansi ayilinganiswa, kepha ibikezelwa ngokukhishwa okuvela ekuhlolweni komthamo ophezulu. Abameli bokubukwa komthamo ophansi bathi ukuvezwa okuphansi ngokweqile kunenye indlela yokusebenza ngokuphelele - "ukuphazanyiswa kwe-endocrine." Ngokwengeza ngobuqili izigaba ezijwayelekile, ezincike ehomoni, ezingeni lokukhula ezilwaneni ezizalwayo, kungashintshwa izinguquko ezimbi unomphela. Lokhu kufaka ukunwetshwa kwe-prostate nokwanda kokuthambekela komdlavuza kamuva empilweni.
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