Nakhu okusha emgqeni wezindatshana eziphikisa iziphetho zezifundo ze-CAT, ukuthi i-amalgam iphephile ezinganeni, ebhalwe ngomunye wababhali bokuqala. Umugqa wokugcina walokhu okungaqondakali, obukela phansi umphumela wokuhlanganiswa kwamazinyo ekuvezweni kwezihloko ze-mercury, uliphikisa iqiniso lokuthi izifundo ze-CAT ziqinisekisile ukuthi ukubeka i-amalgam kukhulisa i-urine mercury.
Ukuguqulwa kwemiphumela ye-neurobehavioral ye-mercury ngama-polymorphisms wezakhi zofuzo we-metallothionein ezinganeni
UJames S. Woods, uNicholas J. Heyer, uJoan E. Russoc, uMichael D. Martind, uPradeep B. Pillaie, uFederico M. Farina
I-Neurotoxicology neTeratology
Kutholakala ku-inthanethi ngomhlaka 1 Julayi 2013
abstract
IMercury (Hg) ine-neurotoxic, futhi izingane zingathinteka ikakhulu kulo mphumela. Inselelo enkulu ekhona manje ukukhonjwa kwezingane ezingabanjwa ubuthi beHg ngokukhethekile ngenxa yesimo sofuzo. Sihlolisise umbono wokuthi ukuhlukahluka kofuzo kwe-metallothionein (MT) okubikwa ukuthi kuthinta i-Hg toxicokinetics kubantu abadala kungashintsha imiphumela ye-neurotoxic ye-Hg ezinganeni. Izingane ezingamakhulu amahlanu nesikhombisa, ezineminyaka engu-8-12 ubudala ekuqaleni, zibambe iqhaza esivivinyweni somtholampilo sokuhlola imiphumela ye-Hg kusuka ekugcwalisweni kwamazinyo e-amalgam. Izihloko zahlolwa ngesikhathi sokuqala nangezikhathi ezingama-7 ezalandela zonyaka zokusebenza kwe-neurobehaisheral kanye namazinga we-urg Hg. Ngemuva kokuphothulwa kwesivivinyo somtholampilo, senze izivivinyo ze-genotyping zokuhlukahluka kwe-MT isoforms MT1M (rs2270837) kanye ne-MT2A (rs10636) kumasampula webhayoloji anikezwe yi-330 yabahlanganyeli besilingo. Kusetshenziswe amasu wokumodela ukucubungula izinhlangano eziphakathi kwesimo se-allelic, ukuvezwa kwe-Hg, kanye nemiphumela yokuhlolwa kwe-neurobehavioral. Phakathi kwamantombazane, ukuxhumana okumbalwa okuphawulekayo noma imiphumela emikhulu yokuzimela yokuvezwa kwe-Hg kanye nokunye kokuhlukahluka kohlobo lwe-MT kubonisiwe. Ngokuphambene nalokho, phakathi kwabafana, imiphumela eminingi ebalulekile yokuxhumana phakathi kokuhlukahluka kwe-MT1M ne-MT2A, iyodwa futhi ihlanganisiwe, nokuvezwa kwe-Hg kubonwe kudlula izizinda eziningi zomsebenzi we-neurobehavioral. Zonke izinhlangano zokuphendula ngomthamo phakathi kokuchayeka kwe-Hg nokusebenza kokuhlolwa bekunqunyelwe abafana kuphela futhi bezisendleleni yokusebenza kabi. Lokhu okutholakele kuphakamisa ukwanda kokuthinteka emiphumeleni emibi ye-HG phakathi kwezingane ezinokuhlukahluka okujwayelekile kofuzo kwe-MT, futhi kungahle kube nemiphumela ebalulekile yezempilo yomphakathi kumasu esikhathi esizayo ahlose ukuvikela izingane nentsha ezingcupheni zezempilo ezingaba khona ezihambisana nokuvezwa kwe-Hg. Siyabona ukuthi ngenxa yokuthi i-urg Hg ikhombisa inkomba yokuvezwa eyinhlanganisela engenakubalwa kumthombo othile, lokhu okutholakele akusekeli ukuhlangana phakathi kwe-Hg kuma-amalgams wamazinyo ikakhulukazi kanye nemiphumela emibi ye-neurobehavioral ebonwe.
Chofoza lapha ukuze funda yonke le ndatshana.
